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- Generic name: Rabeprazole
- Developer: Eisai Company
- Marketer: Janssen-Cilag
- FDA approved: August 19, 1999
- Drug Class: Proton pump inhibitor
- Availability: Prescription only
- Route: Oral
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Aciphex is the brand name of rabeprazole, a potent inhibitor of acid secretion which is prescribed to prevent heartburn and treat conditions like gastroesophageal reflux disease and ulcers. It is also used with antibiotics to treat certain gastric infections.Mayo Clinic: Rabeprazole In the United States, Aciphex is only available with a prescription, since the Food and Drug Administration approved it on August 19, 1999.FDA: Aciphex Consumer Information
Mechanism of Action
Aciphex blocks the H+/K+ ATPase enzyme, which in the gastric parietal cell, normally pumps protons (H+) into the stomach. Consequently, the H+ are not pumped into the stomach and do not combine with Cl- to make hydrochloric acid (HCl).FDA: Aciphex Consumer InformationUses
- Gastroesophageal reflux disease
- UlcersMayo Clinic: Rabeprazole
- Helicobacter pylori infections
- Zollinger-Ellison SyndromeMayo Clinic: Rabeprazole
- Barrett's Esophagus
Interactions
May interact with- AtazanavirMayo Clinic: Rabeprazole
- ClopidogrelMayo Clinic: Rabeprazole
- DasatinibMayo Clinic: Rabeprazole
- ErlotinibMayo Clinic: Rabeprazole
Manufacturer
Eisai Co., Ltd. is the manufacturer of rabeprazole.[Eisai Parent Company It is one of the 25 largest pharmaceutical manufacturers in the world, and is headquartered in Tokyo, Japan.[Eisai Parent Company Over 1/10th of Eisai employees are in research. Another drug Eisai developed is donepezil(brand name Aricept).-
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Aciphex on Amazon
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Aciphex: A Medical Dictionary, Bibliography, And Annotated Research Guide To Internet References - $28.95
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