In the only regular-season game on the 2010 NFL schedule that is played on a Saturday, the week 16 2010 Saturday game featured the Arizona Cardinals defeating the Dallas Cowboys 27-26 on Christmas Day, December 25, 2010. The game began at 7:30 p.m. EST and aired on the NFL Network live from the University of Phoenix Stadium in Glendale, Arizona.http://www.nfl.com/gamecenter/2010122500/2010/REG16/cowboys@cardinals/preview

Both teams entered the game statistically eliminated from qualifying for the 2010-11 NFL Playoffs. The Cowboys brought a 5-9 overall record including going an even 3-3 in road games. The Cardinals went 4-10 through the first 15 weeks of the 2010 National Football League season including winning three-of-seven home games.http://scores.espn.go.com/nfl/nflpreview?gameId=301225022

The Cardinals dominated the game early, including building a 14-point lead in the first quarter. The first touchdown came as a result of an interception thrown by Dallas quarterback Jon Kitna which was grabbed by Dominique Rodgers-Cromartie and returned 32 yards. The second score also came from an interception when Gregory Toler returned the ball 66 yards for a touchdown. Teams played to a 21-10 score with the Cardinals ahead at the half. Arizona quarterback John Skelton threw a 74-yard touchdown pass to Andre Roberts while the Cowboys added a 42-yard field goal by David Buehler and a touchdown in a pass from Kitna to Jason Witten.http://scores.espn.go.com/nfl/boxscore?gameId=301225022

Dallas came back in the third quarter to bring the game to 20-21. Buehler added a second field goal while Marion Barber ran the ball in for a 24-yard touchdown. After a field goal by the Cardinals in the fourth quarter, Dallas briefly took the lead when Stephen McGee threw a 37-yard touchdown pass to Miles Austin. In the final seconds of the game, Cardinals kicker Jay Feely made the game-winning field goal from 48 yards.http://scores.espn.go.com/nfl/boxscore?gameId=301225022